FermenGIN

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Science & Technology

You might not benefit from taking ginseng supplement.

Difference of intestinal microbiome between individuals

Study design
Study design 설명 표 입니다.
Study In-vitro
Purpose To measure the ginsenoside
transforming activity of human
intestinal microbial flora
X axis Left : Ginsenoside Rb1 treatment
Right : Ginseng extract treatment
Y axis Ginsenoside transforming activity
of microbial flora
Study design 설명 표 입니다.
Study Clinical pharmacokinetics
Purpose To measure the intestinal
absorption of ginseng extract
X axis Blood sampling time
Y axis Plasma concentration of compound K (analytical marker of the final metabolite of ginsenoside)
Outcomes
  • Ginsenoside transforming activity of intestinal microbial flora differs between individuals.
  • The absorption rate of Compound K differs between individuals due to differences in intestinal microbial flora.

    * Ref. Lee J. et al., J. Ethnopharmacol., 2009, 122(1):143-148

Main causes of individual difference

  • Dietary habits

  • Genetic background

  • Intestinal microbiome condition

Most ginsenoside compounds come with relatively higher molecular weight
when extracted by conventional methods and
they could not be absorbed into the body depending on individuals.

We do genuine fermentation

Quality marker of the fermentation
Ginsenoside Compound K
  • Ginsenoside Compound K is the final form of ginsenoside Rb1.
  • Ginsenoside Compound K is not found in white and red ginseng.
  • Presence of ginsenoside Compound K is evidence of high-quality fermentation.
Ginsenoside F2
  • F2 is intermediate between ginsenoside Rb1 and ginsenoside Compound K.
  • Presence of F2 with compound K is a trace of fermentation through microorganisms.
HPLC Chromatogram
  • High molecular ginsenosides
  • Low molecular ginsenosides
Before fermentation
  • High molecular ginsenosides
  • Low molecular ginsenosides
After fermentation

At every single batch, we make sure of the presence of specific marker ginsenosides
that are created by the fermentation method.

Enhanced bioavailability

Human pharmacokinetic study

Study design
Studyrtt design 설명 표 입니다.
Daily Dose Trial Period Participants Design
5 g 24 hours 13 healthy males Double-blind, randomized, crossover

Outcomes

FermenGIN vs Normal red ginseng extract

  • Compound K

  • F2

  • Rk1+Rg5

  • Rg3

Rg3, Rk1+Rg5, F2, and CK ginsenosides showed
higher Cmax, AUC(0-t), and AUC(0-∞) after oral administration of FermenGIN,
compared with red ginseng extract.
The significant increase in the AUC and Cmax of ginsenosides indicates that
FermenGIN ginsenosides were absorbed better than red ginseng extract.

Sensory improvement

Cyclodextrin encapsulation technology

In aqueous solution, the inner cavity of γ-cyclodextrin makes chemical bonds with hydrophobic ginsenosides as known
as bitter-tasting compounds and it forms a ginseng saponin-cyclodextrin complex.
When the complex is formed, it is difficult to feel bitter taste because ginseng saponin is not able to reach the receptor of the tongue.

Human sensory evaluation

Test design
Studyrtt design 설명 표 입니다.
Test sample Concentration Panel
Normal red ginseng extract 0.1% 64
FermenGIN 0.1%
Outcomes
FermenGIN vs Normal red ginseng extract
  • Bitterness
    • Normal Red Ginseng
    • FermenGIN®
  • Sweetness
    • Normal Red Ginseng
    • FermenGIN®

According to the statistical data of panel responses, it turned out FermenGIN is
less bitter by 14% and sweeter by 16% than normal red ginseng extract .